Based on the food concentration of DYR21954 that was previously shown to decrease Aβ42 and Tau pathology and to reverse cognitive deficits of AD mice, we fed control (elav-Gal4/+) or flies overexpressing AD associated human Tau 0N4R in all neurons (elav > Tau) 304 μM DYR219 and 248 μM DYR533. The gene discussed is MAPT; the disease is Alzheimer disease.