Our findings show mnb is functionally conserved with DYRK1A, with mice overexpressing mouse Dyrk1a or human DYRK1A having similar motor and cognitive deficits, suggesting that triplication of DYRK1A likely contributes to pathology and behavioural deficits in DS and AD-DS36,37,39,41. Here, DYRK1A is linked to Dravet syndrome.