As human Tau, amyloid-β and DYRK1A have been associated with neurodegeneration in AD and AD-DS, we wished to confirm if these molecules were also neurotoxic in Drosophila. We overexpressed in the eye throughout developmental and adulthood human Tau 0N4R, human amyloid-β42 (Aβ42) and the fly orthologue of DYRK1A called minibrain (mnb) using the Glass multimer reporter (GMR-Gal4) promoter24,50. The gene discussed is DYRK1A; the disease is Alzheimer disease.