We also confirmed that IKAROS (encoded by IKZF1) is a dependency in KMT2A (MLL1)-rearranged (MLL1-r) and mtNPM1-expressing AML cells [15], by demonstrating that CRISPR knockout of IKZF1 significantly increased sensitivity of OCI-AML3 cells to ziftomenib (Supplementary Figs. S4A and S4B). Here, IKZF1 is linked to acute myeloid leukemia.