Like the conventional SGs induced by arsenite, eSGs contained multiple stress granule markers, including two RBPs, HUR and PABP, a translation initiation factor eIF4G, a 40S ribosomal subunit RPS6, and an ALS/FTD-associated RBP TDP-43 (Fig. 1b and Supplementary Fig. 1c, d). This evidence concerns the gene RPS6 and amyotrophic lateral sclerosis.