Given that sodium selenite is known to cause translation inhibition and trigger an unconventional type of stress granule by inducing 4EBP1 dephosphorylation44, we hypothesized that severe energy deficiency blocks the initiation of protein translation and triggers eSG formation through 4EBP1 dephosphorylation resulting from mTOR inactivation. This evidence concerns the gene EIF4EBP1 and hyperinsulinemic hypoglycemia, familial, 4.