Several O-GlcNAcylation targets related to PDAC metabolism and progression, such as notch receptor 1 promoting cancer development [66], SRY-box transcription factor 2 regulating self-renewal [67], sirtuin 7 (SIRT7) triggering cancer progression by blocking the SIRT7-proteasome activator subunit 3 (PAME3) interaction [68], and nuclear factor kappa B modulating cancer-associated inflammation [69], have been reported. This evidence concerns the gene SOX2 and cancer.