CD8A and Zika virus infectious disease: Certain protective responses identified during ZIKV infection could be mediated by CD8 T cells that specifically recognize structural proteins such as E, precursor membrane (prM), and C in non-DENV-exposed individuals (88), while CD4 T cell responses are primarily directed against nonstructural proteins such as NS3, NS4B, and NS5 after exposure to DENV (89, 90).