ENPP1 and arterial calcification, generalized, of infancy, 1: The clinical presentation of ENPP1 Deficiency in infants, typically described as GACI, is characterized by arterial calcification, stenosis of large and medium‐sized vessels and severe CV problems such as systemic hypertension, pulmonary hypertension, heart failure, cardiomyopathy or myocardial ischemia/infarction (Ferreira, Hackbarth, et al., 2021; Rutsch et al., 2008).