A similar pattern was also evident for nonflagellin surface and secreted proteins of Clostridiales since also overrepresented in healthy controls to patients with severe ME/CFS were antibody responses against toxin A from Lachnospiraceae and Eubacterium, an adhesin protein from Blautia obeum, and a Lachnospiraceae MurNAc-LAA (N-acetylmuramoyl-l-alanine amidase) domain containing protein involved in cell wall modifications. The gene discussed is PGLYRP2; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.