The protein products of TP53 and RB1 genes, which are well known to be genetically altered in SCLC,57, 58, 59 were quantified in 100.0% and 88.5% of the cell lines, respectively, independent of the previously described TP53 and RB1 mutational status of the cell lines35 (Figure S2b). This evidence concerns the gene RB1 and small cell lung carcinoma.