In the adjusted analyses of combined phthalate metabolites, the composite scores of HMW metabolites or some groupings of HMW metabolites were associated with low SHBG concentrations (regression coefficient, –0.09 [95% CI, –0.13 to –0.05]) and obesity (RR, 1.12 [95% CI, 1.04-1.21]) (eTables 6 and 7 and eAppendix in the Supplement). This evidence concerns the gene SHBG and obesity disorder.