A total of 230 women (11.8%) had high TT levels (median, 20.2 ng/dL; IQR, 13.6-29.0 ng/dL), 210 (10.4%) had low SHBG levels (median, 567.6 μg/mL; IQR, 379.9-838.9 μg/mL), 825 (39.8%) had obesity (BMI: median, 27.9; IQR, 23.5-33.4), and 965 (45.5%) had metabolic syndrome (weighted percentages). The gene discussed is SHBG; the disease is obesity due to melanocortin 4 receptor deficiency.