CTLA4 and hypophysitis: Out of 276 patients with hypophysitis described in the literature between 2003 and 2019, 70% were secondary to CTLA-4 blockade, 23% to PD-1 blockade, 2% to PD-L1 blockade, and 3.9% to combination therapy (CTLA-4 and PD-1) (31, 32).