Patients with squamous cell carcinoma or PD-L1 expression < 1%, who were identified as having a high risk for LR, presented a lower percentage of DM as initial recurrence in the CCRT+D cohort than in the CCRT cohort (39.5% vs 63.6%), although the percentage of LR was similar in the CCRT+D and CCRT cohorts (39.5% vs 45.5%) (Fig. 3a). This evidence concerns the gene CD274 and squamous cell carcinoma.