Such as, CN-LOH (4q24) in MDS promoted the discovery of TET2 gene mutation [25]; CN-LOH (11q) in CMML promoted the identification of CBL gene mutation [26, 27], and CN-LOH (17p) in MDS/sAML promoted the confirmation of TP53 gene mutation [28]. This evidence concerns the gene TP53 and chronic myelomonocytic leukemia.