Greenet al. [38] found that a specific inhibitor of mTOR induces a multisite dephosphorylation of 4E-BP1, which markedly inhibits the initiation step of mRNA translation, resulting in a strong anti-leukemic activity against primary AML cells while sparing normal hematopoiesisex vivo and significantly reducing the growth of AML cells in nude mice. This evidence concerns the gene EIF4EBP1 and acute myeloid leukemia.