Considering the important role of IFNγ in the pathogenesis of schistosome-induced hepatic fibrosis[20], we also investigated the effect of IFNγ on miR-182 expression, and our data indicated that IFNγ significantly reduced miR-182 expression in hepatocytes and knockdown of miR-182-5p decreased the expression of fibrosis-related cytokines. This evidence concerns the gene IFNG and Hepatic fibrosis.