By exploring the transcriptome characteristics for cell clusters in the positive lymph node with breast cancer metastasis, we identified that metastatic cancer cells distribute in most areas of the positive lymph node and the top differentially expressed genes includedNPY1R,AGR2,XBP1,RPL13,AGR3,IL6ST,FTL,COL6A2, andGATA3 (P<0.0000). This evidence concerns the gene XBP1 and metastatic malignant neoplasm.