Most of the activating EGFR mutations detected in NSCLC are located in the kinasedomain, with L858R in exon 21 and small in-frame deletions in exon19 being observed most frequently.11,12 In contrast, EGFR mutations found in glioblastoma are typically locatedin the extracellular module.5 Here, EGFR is linked to glioblastoma.