For example, Stein et al. analyzed 247 NSCLCsamples and detected 43 EGFR mutations, of which7 were located outside of the kinase domain.11 Thus, while the kinase domain indeed seems to be the mutation hotspot within the EGFR gene in lung cancer, mutationsare also found in other parts, most notably in the extracellular domain.11 In contrast to NSCLC, it is known that in glioblastomathe majority of EGFR mutations are located in theextracellular domain.5,37. The gene discussed is EGFR; the disease is lung cancer.