More than 1000 distinct amino acid pointmutations in the EGFR gene have been listed in theCatalogue of Somatic Mutationsin Cancer (COSMIC).17,18 We hypothesized that, in additionto the well-known EGFR mutations, there would beadditional activating mutations that have not been functionally testedyet due to their low frequency in human cancer. Here, EGFR is linked to cancer.