While the decrease in the frequency of CD27+ IgD+ Unswitched B cells (USM) seems to be a widespread change in most SLE patients (11), other changes, such as an expansion of recently described extrafollicular effector double negative type 2 (DN2) and activated naive (aNAV) B cells, are specific to specific patient subgroups such as patients of African American ancestry with active disease status and renal involvement (12). Here, CD27 is linked to systemic lupus erythematosus.