Accordingly, the observed correlation between some parameters and the development of granuloma inflammation in the tissues has revealed markers for sarcoidosis progression, namely increased levels of neopterin molecule synthesized from macrophages, sIL-2R marker of T-cell activation, chitotriosidase secreted by active macrophages, neutrophil-derived collagenase and elastase (50), and a low level of TNF-α synthesized from alveolar macrophages and T-cells (51). Here, TNF is linked to Granuloma.