ICOS and sarcoidosis: Sakthivel et al. (12) demonstrated that patients with sarcoidosis showed a high-level ICOS expression restricted to inflamed lung T-regs in comparison to blood T-regs of patients with sarcoidosis and to lung and blood T-regs of healthy volunteers; moreover, ICOS expression resulted significantly higher in lung T-regs than in sarcoid-specific lung effector T cells.