FOXP3 and sarcoidosis: Intriguingly, the ratio between IFN-γ+ Th17 cells and T-regs expressing FoxP3 transcription factor, was markedly increased in sarcoidosis: this finding suggested a possible immune cell imbalance in sarcoidosis, especially in relation to an impaired function of regulatory T cells which have a fundamental role in maintaining immune homeostasis and preventing autoimmunity (10).