Their findings disclosed a high immunological reactivity, in patients with sarcoidosis, toward four proteins: ZNF688, a zinc finger protein with as-yet unclear functions in the sarcoidosis context; NCOA2, a protein that modulates nuclear hormone receptor activity; MRPL43, a mitochondrial ribosome related protein; ARFGAP1, expressed in several cell types, including alveolar macrophages that play a key role in the defense against inhaled microorganisms, also involved in sarcoidosis granuloma formation and disease outcome (21). This evidence concerns the gene ARFGAP1 and sarcoidosis.