A significant association was found between the IFNGR1 rs2234711 polymorphism and TB susceptibility among Africans in dominant model (OR = 1.24, 95%CI:1.01–1.52), and among Asians in allele model (OR = 0.89, 95%CI: 0.79–0.99), homozygote model (OR = 0.82, 95%CI: 0.70–0.98) and additive model (OR = 0.90, 95%CI: 0.83–0.97). The gene discussed is IFNGR1; the disease is tuberculosis.