In line with previous reports (23–25, 30), the reduction in the total number of conventional DCs in the spleen (Supplementary Figures 1A, B) was mainly based on a loss of the CD4+ DC2 subset that was evident 24 h after induction of sepsis and that was maintained at least 4 days after CLP (Supplementary Figure 1C). Here, CD4 is linked to Sepsis.