In a previous study, we observed severe interstitial fibrosis in the contralateral kidney in a 6-month unilateral ureteral obstruction (UUO) rat model, which was accompanied by increased macrophage infiltration and phenotypic transformation; after treatment with the mineralocorticoid receptor (MR) antagonist eplerenone, these effects were reduced (9). This evidence concerns the gene NR3C2 and Ureteral obstruction.