NR3C2 and renal fibrosis: In conclusion, we performed in vitro and in vivo experiments and showed that ALD-mediated MR activation upregulated the expression of TGF-β1 and induced the transformation of macrophages, especially M1 macrophages, to myofibroblasts to participate in renal fibrosis, and the MR blocker esaxerenone antagonized these effects.