Therefore, we hypothesized that the inflammatory milieu within the RA synovium co-stimulates osteoclasts by ACPA autoimmune complexes and IFNγ; thus, FcγR-ITAM and IFNγR signaling co-influences the differentiation of monocytes into active bone-resorbing osteoclasts. The gene discussed is IFNGR1; the disease is rheumatoid arthritis.