The more routine methods of determining the infection status include detection of antibodies against nuclear antigen-1 (EBNA-1), early antigen (EA), viral capsid antigen (VCA-IgM and VCA-IgG), noncoding RNA protein (EBERs) and, in certain indications—mainly in patients after transplantation with a suspected post-transplant lymphoproliferative disease (PTLD)—a PCR testing for the presence of EBV-DNA. Here, CD40LG is linked to infection.