There are studies showing the role of IL-6 in pSS, revealing the increased levels of IL-6, IL-17A, and nitrogen oxide in the serum and saliva of pSS patients compared to the healthy control group (48) and the correlation of IL-6 levels with the extent of mononuclear cell infiltration in salivary and lacrimal glands. The gene discussed is IL17A; the disease is peeling skin syndrome.