In the field of CNSTs, Saha et al., reported the synergistic interaction between G47Δ⁃mIL⁃12, an oncolytic HSV encoding IL-12, and ICIs (anti-PD-1 and anti-CTLA-4) in curing glioblastoma and inducing immunological memory (73). Here, CTLA4 is linked to glioblastoma.