Using pGSN, CRP, IgG, IgM or IgA alone were not significantly predictive, however the AUCs of pGSN/IgG and pGSN/IgM to predict severe COVID-19 were 0.893 (p=0.028) and 0.96 (p=0.01) respectively (Figure 4A;Supplementary S4A). Here, CD40LG is linked to COVID-19.