TOB1 and metastatic malignant neoplasm in the lymph nodes: found that overexpression of lncRNA-CASC8 resulted in up-regulation of TOB1 and low expression of miR-129-5p, which were associated with an increased frequency of lymph node metastasis and a higher trend of pathological stage, respectively, thus validating the CASC8-miR-129-5p-TOB1 regulatory axis (58).