IL-10 also reduced SEB-induced IFN-γ response in the spike-responders of COVID-19 patients [15.21 (12.12-17.35) vs 7.52 (1.94-16.22), p=0.0067] (Figure S4A); as well as in NO COVID-19-VCs, although the difference of SEB-induced IFN-γ response did not reach significance (p>0.016) (Figure S4B). The gene discussed is IFNG; the disease is COVID-19.