Immune-Checkpoint-Blockage (ICB) therapies targeting the axis Programmed-Cell-Death-Protein-1(PD-1)/Programmed-Cell-Death-Ligand-1(PD-L1) showed considerable success in treating several carcinomas, including the advanced bladder urothelial carcinoma (aBUC) presenting progressive disease and conventional therapies resistance (16, 17). Here, PDCD1 is linked to bladder transitional cell carcinoma.