Studies have shown that when myeloid leukemia cells were co-cultured with HIV-1 protease inhibitor and ATRA, HIV-1 protease inhibitor can up-regulate the expression of C/EBPε messenger RNA in the retinoic acid signaling pathway, thereby enhancing the inhibition role of ATRA on the induction immune cells differentiation, which was induced by myeloid leukemia cell (58). Here, CEBPE is linked to myeloid leukemia.