The AP-1 is the transcription factor-binding sites in the gene promoter that initiates the activation of WFDC12 gene expression, which plays an important function as a disease-related transcriptional regulatory activator in psoriatic KCs (40), and continuously up-regulated small proline-rich protein 1A (SPRR1A0), gap junction protein alpha 1 (GJA1), and early growth response 1 (EGR1) genes expression in damaged skin. Here, SPRR1A is linked to dry eye syndrome.