To further determine the potential role of WFDC12 in the pathogenesis of psoriasis, first, K14-WFDC12 mice were constructed (Figures S1A–C).Compare with wild-type (WT) mice, the WFDC12 expression increased in K14-WFDC12 transgenic mice in back skin (Figure S1D). The gene discussed is KRT14; the disease is psoriasis.