CD4 and psoriasis: After IMQ-induced psoriasis, the proportion of Th1 cells that secrete IFN-γ (CD3+CD4+IFN-γ+) in the lymph nodes of K14-WFDC12 transgenic mice was higher than that of WT mice (Figures 4A, B), whereas Th17 cells that secrete IL-17 (CD3+CD4+IL-17+) has no statistically significant differences between two IMQ-induced psoriasis groups (Figures 4A, C), but compared with WT mice, the differentiation of Th17 cells in lymph nodes of K14-WFDC12 transgenic mice showed an overall trend of increase.