It was indicated that WFDC12 may induce the differentiation of Th1 cells in the lymph nodes by regulating the infiltration of DC cells in the skin lesions and lymph nodes (including LCs and moDDCs) and increase the secretion of IFN-γ in the skin lesions, thereby exacerbating the pathogenesis of psoriasis. Here, IFNG is linked to psoriasis.