To investigate the relevant mechanisms of WFDC12 in psoriasis, the iTRAQ-based proteomics profiling was performed to compare the expression of the different genes in the back skin lesions of WFDC12 transgenic mice and WT mice after IMQ treatment, discovering significant alterations of genes expression that was relative to the retinoic acid signaling pathway in transgenic mice based on the GO analysis, string analysis, and KEGG signaling pathway results, including CRABP1, DHRS9, and RDH10. This evidence concerns the gene RDH10 and psoriasis.