Based on the iTRAQ proteomic profiling methods, we have initially explored the relevant mechanisms of WFDC12 regulating psoriasis; the results showed that the exacerbated inflammation in K14-WFDC12 mice may be caused by the change of retinoic acid signaling pathway, providing a new theoretical basis for the exploration of new targets and ideas in clinical psoriasis treatment and diagnosis. Here, KRT14 is linked to psoriasis.