In the proteome profiling data of the IMQ-induced psoriasis model, the expression of RDH10 and DHRS9 was down-regulated in the lesion of K14-WFDC12 transgenic mice, meaning that a critical step in the creation of retinoic acid ATRA was blocked, resulting in a decrease in retinoic acid ATRA synthesis. The gene discussed is RDH10; the disease is psoriasis.