And the decreased concentration of retinoic acid may have resulted in the downregulation of RDH10 and DHRS9 and the upregulation of CRABP1 expression of the back skin lesions of K14-WFDC12 transgenic mice, thereby regulating the expression of IL-12 in dendritic cells and inducing Th1 cells of differentiation. The gene discussed is CRABP1; the disease is neoplasm.