In an attempt to identify potential kinase(s) that regulate the phosphorylation of STAT2 at Y690 at the early stage of viral infection, we found that Syk and MAPK12 may be involved in the early activation of STAT2 upon IAV infection, as depletion of Syk or MAPK12 significantly decreased STAT2 activation at the early stage of viral infection. Here, MAPK12 is linked to viral infectious disease.