In the present study, we found that ARPC5 expression was significantly upregulated in most cancer types basing on the TCGA datasets integrating with GTEx datasets, including GBM, LGG, BRCA, CESC, ESCA, KIRP, COAD, PRAD, STAD, HNSC, KIRC, LUSC, LIHC, SKCM, BLCA, THCA, OV, PAAD, TGCT, and CHOL. This evidence concerns the gene ARPC5 and glioblastoma.