Previous studies found that Arp2/3 subunits are highly expressed in a variety of cancers and promote the tumorigenesis and development, including pancreatic cancer (5, 6), breast cancer (7–9), lung squamous cell carcinoma (10), prostate cancer (11), gastric cancer (12), colorectal cancer (2), and bladder cancer (4). Here, ACTR2 is linked to cancer.