In the present study, we found that ARPC5 expression was significantly upregulated in most cancer types basing on the TCGA datasets integrating with GTEx datasets, including GBM, LGG, BRCA, CESC, ESCA, KIRP, COAD, PRAD, STAD, HNSC, KIRC, LUSC, LIHC, SKCM, BLCA, THCA, OV, PAAD, TGCT, and CHOL. Here, ARPC5 is linked to cancer.