Baseline age, HBsAg were negative factors for week 48 HBsAg seroconversion, while gender, HBV-DNA negative duration, baseline ALT, AST, TB, ALB, HBeAg seroconversion, combined ETV or TDF or TAF, interferon alone, interferon-experienced were not an associated factor for week 48 HBsAg seroconversion (Table 5). The gene discussed is ALB; the disease is tuberculosis.