In this current meta-analysis, we aimed to systematically review RCTs involving patients with heart failure with preserved LVEF and identify the effects of various treatment options [angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, angiotensin receptor blockers, and aldosterone receptor blockers] on all-cause mortality, cardiovascular mortality, and hospitalization due to cardiovascular reasons. The gene discussed is ACE; the disease is heart failure.