PRNP and neuroblastoma: The incubation of neuroblastoma cells with a misfolded (Corsaro et al., 2006; Chiovitti et al., 2007), neurotoxic (Thellung et al., 2013, 2017) recombinant PrP peptide was shown to impair the proteostatic machinery leading to cathepsin D leakage from lysosomes and inhibition of the normal autophagic flux that lead to cell death (Thellung et al., 2011, 2018).