Moreover, the capacity of a pathological protein to recruit its physiological counterpart driving its spatial refolding, which originally was described as a unique property of PrPSc, has been recently proposed to play a role also in the pathogenesis of Alzheimer's and Parkinson's diseases, as a mechanism favoring intracellular aggregation of hyperphosphorylated tau and α-synuclein (Caughey and Kraus, 2019; Duyckaerts et al., 2019). Here, MAPT is linked to Parkinson disease.