MTOR and neuroblastoma: Astemizole, an H1 histamine receptor antagonist, has the capacity to inhibit mTOR signaling and is able to prevent PrPSc replication in a persistently infected neuroblastoma cell line, prolonging the survival of mice infected with intracerebral inoculation of RML scrapie prion (Karapetyan et al., 2013; Lyu et al., 2018).