Chemokine (C-X-C Motif) ligand 12 (CXCL12) is a target gene of miR-135a-5p and thus miR-135a-5p inhibited the activation of the JAK2/STAT3 signaling pathway to reduce inflammatory reaction and myocardial cell apoptosis in MI (16). The gene discussed is CXCL12; the disease is myocardial infarction.