PTGS2 and B-cell non-Hodgkin lymphoma: Activation of cell surface tyrosine kinase receptors promoted phosphorylation of the tyrosine 705 site of STAT3 to form dimers and enter the nucleus for DNA binding to upregulate gene transcription, such as anti-apoptotic (B cell lymphoma/leukemia-2 (Bcl-2), B cell lymphoma/leukemia-xl (Bcl-xl), myeloid cell leukemia-1 (Mcl-1), FLICE [Fas-associated death domain-like IL-lbeta-converting enzyme-inhibitory protein (c-FLIP)], anti-oxidative (MnSOD and Metallothionein MT1/MT2), and cardioprotective [Cyclooxygenase-2 (COX-2) and heme oxygenase (HO-1)] proteins (5).