Exogenous overexpression of AKAP12 in Lovo colon cancer cell line inhibits tumor cell proliferation, migration, and invasion ability [18]; in contrast, AKAP12 silencing or AKAP12/HDAC3 cosilencing promotes tumor cell proliferation, colony-forming ability, and cell cycle progression [20]. This evidence concerns the gene AKAP12 and malignant colon neoplasm.