Sulforaphane (SFN), an inhibitor of HDAC2, can reverse renal interstitial fibrosis induced by high glucose (HG/Pal) by inhibiting HDAC2 and reactivating the BMP-7-Smad1/5/8 pathway in the mouse streptozotocin (STZ)-induced diabetes model. Here, HDAC2 is linked to diabetes mellitus.