In renal tubular epithelial cells, SIRT6 binds to β-catenin and mediates histone deacetylation near the promoters of fibronectin, MMP7, and snail, exerting a protective effect against renal fibrosis by inhibiting their transcription (Cai et al., 2020; Gewin, 2020). The gene discussed is FN1; the disease is renal fibrosis.