To investigate whether INPP4B restrained PD-L1 expression by glioma cells through interfering with PI3K/AKT signaling, U87 cells were transfected with pcDNA3.1-Scramble or pcDNA3.1-INPP4B for 48 h with or without 740 Y-P, and surface PD-L1 was analyzed by flow cytometry. This evidence concerns the gene INPP4B and central nervous system cancer.