As shown in Table 1, N stage, distant metastasis, age, and FGFR4 were independent prognostic factors for GC patients, while FGFR1, FGFR2, and FGFR3 had no significant association with an increased risk of GC and poor OS and PFS in univariate or multivariate analyses. The gene discussed is FGFR4; the disease is gastric cancer.