However, Ada mRNA levels (Figure 4I) were found decreased in combination treatment (RFA+AB680) when compared to both RFA (p<0.05) and RFA+VEH (p<0.01), suggesting CD73 inhibition with AB680 effectively reduced the capability of the tumor to produce INO when ADO generation is being inhibited by CD73 activity blockade. Here, ADA is linked to neoplasm.