However, Ada mRNA levels (Figure 4I) were found decreased in combination treatment (RFA+AB680) when compared to both RFA (p<0.05) and RFA+VEH (p<0.01), suggesting CD73 inhibition with AB680 effectively reduced the capability of the tumor to produce INO when ADO generation is being inhibited by CD73 activity blockade. The gene discussed is ADO; the disease is neoplasm.