BRCA1 and breast carcinoma: Seventy patients were discovered to harbor germline LGRs in BRCA1 and 14 in BRCA2. Both in ovarian cancer and breast cancer, the BRCA1/2 germline variant was more frequently observed than the BRCA1/2 somatic variant (ovarian cancer, BRCA1/2 germline, 369/2526, 14.6%; BRCA1/2 somatic, 127/2526, 5.0%; breast cancer, BRCA1/2 germline, 170/1788, 9.5%; BRCA1/2 somatic, 43/1788, 2.4%), which were comparable to the findings of previous studies (15–18).