Genes associated with the neuronal differentiation pathway (Pcsk9, Runx1, Cebpb, Fzd4, Wnt7a, Ascl1, Fzd2, Edn3, Olig2, and Gpc2), gliomas (Shc1, Cdk4, E2f2, and Ccnd1), and cell cycle (Bub1b, Bub, Ccnb1, Ccnb2, and Cdc20) were significantly downregulated (Figures 5B,D). The gene discussed is CCNB1; the disease is central nervous system cancer.