Genes associated with the neuronal differentiation pathway (Pcsk9, Runx1, Cebpb, Fzd4, Wnt7a, Ascl1, Fzd2, Edn3, Olig2, and Gpc2), gliomas (Shc1, Cdk4, E2f2, and Ccnd1), and cell cycle (Bub1b, Bub, Ccnb1, Ccnb2, and Cdc20) were significantly downregulated (Figures 5B,D). The gene discussed is BUB1B; the disease is glioma.