Genes associated with the neuronal differentiation pathway (Pcsk9, Runx1, Cebpb, Fzd4, Wnt7a, Ascl1, Fzd2, Edn3, Olig2, and Gpc2), gliomas (Shc1, Cdk4, E2f2, and Ccnd1), and cell cycle (Bub1b, Bub, Ccnb1, Ccnb2, and Cdc20) were significantly downregulated (Figures 5B,D). This evidence concerns the gene CDK4 and central nervous system cancer.