Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening condition characterized by persistent activation of T lymphocytes and macrophages, leading to the hypersecretion of pro-inflammatory cytokines, including interleukin (IL)-1, IL-6, IL-18, tumor necrosis factor (TNF), and interferon-gamma (IFNγ) (1). This evidence concerns the gene TNF and hemophagocytic syndrome.