Furthermore, Dawson et al. demonstrated that BET inhibition could exhibit profound anti-leukemic effects against human and murine MLL-fusion leukemic cell lines, and they also identified the effects in mouse models of murine KMT2A::MLLT3 and human KMT2A::AFF1 (previously MLL::AF4) leukemia (64). Here, AFF1 is linked to leukemia.