The presence of CD45+EpCAM+ cells was reported in solid tumor tissues and malignant effusions of patients with NSCLC and EOC, and our previous study showed exosomes from lung cancer cells fused with CD45+ cells and the micorRNA from the exosomes induced gene expression change that results in EpCAM expression and also making these CD45+EpCAM+ cells prone to apoptosis (20–22). The gene discussed is EPCAM; the disease is non-small cell lung carcinoma.