Moreover, given the relevant role played by inflammation in the testes of our patients (Alfano et al., 2021), it was i intriguing that, recently, MEG3 was found to promote pyroptosis, i.e., a form of cell-death associated with inflammatory signals, in testicular ischemia-reperfusion (IR) injury (Ning et al., 2021). This evidence concerns the gene MEG3 and ischemia.