The resulting ATRA responsive CRC contained previously reported ADRN CRC components, including PHOX2B, TBX2, and KLF7 (Boeva et al., 2017; Durbin et al., 2018; Zimmerman et al., 2021), as well as novel candidates CEBPG, KLF13, TWIST1, and FEV, which were identified in the responsive cell lines but not in the ATRA-resistant SH-EP cell line (Figure 6A, Supplementary Figure S6B). Here, FEV is linked to colorectal carcinoma.