We also saw the suppression of established ADRN core transcription regulatory circuitry (CRC) components PHOX2B, and MYCN in BE2C cells, which stabilize the ADRN CRC in MYCN-amplified cell lines (Supplementary Figure S6A) (Durbin et al., 2018; Zeid et al., 2018; Zimmerman et al., 2021). This evidence concerns the gene MYCN and colorectal carcinoma.