MYC and cancer: During cancer development, cancer cells can acquire super-enhancers near key oncogenes, such as MYC and TAL1 (Hnisz et al., 2013; Herranz et al., 2014; Mansour et al., 2014), and several oncogenic super-enhancers have been found across a broad spectrum of cancers (Sengupta and George, 2017; He et al., 2019).