Furthermore, the overexpression of CD44 suppressed ferroptosis in cancer cells in an OTUB1-dependent manner (Liu et al., 2019), and (Monteleone et al. (2021) demonstrated that inhibiting protein kinase C, which can modulate CD44 expression, is a strategy to sensitize NB stem cells to etoposide by stimulating ferroptosis. Here, OTUB1 is linked to neuroblastoma.