PLCG2 and amyloidosis: The relationship between amyloid plaques and PLCγ2 expression has been supported by increased levels of PLCγ2 throughout disease progression in well-studied models of amyloid pathology, 5x, FAD, TgCRND8, and App NL-G-F/NL-G-F mice (Castillo et al., 2017; Magno et al., 2019).